Our Data


Phenotyping

Transforming Electronic Health Record (EHR) data to research appropriate phenotypes is not trivial.  Generating accurate electronic phenotypes involves multiple levels:

  1. Rigorous attention to data quality, completeness, and comparability; and
  2. Recognition and reduction of phenotype heterogeneity through a variety of means, including disease sub-classification, intermediate phenotypic markers based on anatomic, physiologic, cellular, or molecular findings, stratification/adjustment using key covariates, or data reduction/clustering techniques.

Over the last decade, the Phenotyping Core team has developed a variety electronic phenotyping approaches, which use a collection of different clinical measurements, documents, prescriptions, and billing codes to accurately identify valid, robust phenotypes.  Overall, disease incidence and prevalence in the PMRP cohort are similar to those of the general population in the state of Wisconsin.

The Phenotyping Core team is available to assist researchers in characterizing patient populations for a variety of studies.


Access to Data

The Wisconsin Genomics Initiative uses the Informatics for Integrating Biology and the Bedside (i2b2) framework to provide a web-based tool for investigators to obtain summary statistics about the clinical and genetic data available at Marshfield Clinic.  This query tool is only available to registered users.

i2b2 is an NIH-funded National Center for Biomedical Computing based at Partners HealthCare System.  The i2b2 Center is developing a scalable informatics framework that will enable clinical researchers to use existing clinical data for discovery research and, when combined with IRB-approved genomic data, facilitate the design of targeted therapies for individual patients with diseases having genetic origins.  This platform currently enjoys wide international adoption by the CTSA network, academic health centers, and industry.


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Making Personalized Health Care a Reality


The Wisconsin Genomics Initiative is positioned to make the promise of personalized medicine a reality. Combining the cutting-edge technology and intellectual capital from multiple academic research centers, the Wisconsin Genomics Initiative not only aligns with the priorities of the National Institutes of Health, the US Department of Health & Human Services, but also with the Wisconsin Idea.

View the Demonstration Awards 

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